МикроРНК экзосом молока как эпигенетический маркер метаболизма и мастита у коров
https://doi.org/10.25687/3034-493X.2026.6.1.004
Аннотация
Молоко как важнейший источник питания содержит широко известные белки, минералы, витамины и менее известные сигнальные молекулы в виде коротких некодирующих РНК как в свободном виде, так и содержащихся в экзосомах. Состав экзосомального груза динамичен и зависит от физиологического состояния организма, включая стадию лактации и здоровье молочной железы. Данный обзор посвящен теме таких ключевых эпигенетических компонентов, как микроРНК молока, заключенных в экзосомах. В обзоре рассмотрены представления о роли экзосомных микроРНК молока как генетического маркера продуктивности и здоровья молочного скота. Затронута тема формирования экзосом и механизм сортировки экзосомных грузов, большое внимание уделяется этапам биосинтеза микроРНК у млекопитающих и механизма воздействия на геном как главного эпигенетического посттранскрипционного фактора. Описаны работы по изучению профиля микроРНК молока в зависимости от стадии лактации и состояния здоровья молочной железы крупного рогатого скота. Представленные данные будут полезны для понимания организации, регуляции и эпигенетики микроРНК в молоке жвачных животных и открыва.т возможности для разработки новых диагностических и селекционных инструментов в животноводстве.
При поддержке: Исследование выполнено при финансовой поддержке программы государственного задания Российской Федерации № FGGN-2024-0015
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Рецензия
Для цитирования:
Баркова О.Ю. МикроРНК экзосом молока как эпигенетический маркер метаболизма и мастита у коров. Успехи наук о животных. 2026;(1):58-74. https://doi.org/10.25687/3034-493X.2026.6.1.004
For citation:
Barkova O.Yu. Milk exosomal microRNA as an epigenetic marker of metabolism and mastitis in cows. Ernst Journal of Animal Science. 2026;(1):58-74. (In Russ.) https://doi.org/10.25687/3034-493X.2026.6.1.004
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